When Is Mlb Opening Day 2025 Sf Giants. The @sfgiants 2025 schedule has been released. The official start date for the 2025 mlb season is march 18, 2025 , as the dodgers will face the chicago cubs.

San francisco will open the season against the cincinnati reds on march 27 at great american ball park and will wrap up the 2025 campaign against the colorado rockies on september 28 at oracle park. 18—the cincinnati reds will play the san francisco giants on march 27, 2025, at great american ball park on opening day in cincinnati.